Large majority of the US population suffers from depression in one way or the other. It is interesting to note here that people of all ages including teens, adults, and oldies are affected by this mental disease.

There are many reasons of depression; loss in life, illness, loneliness, heredity, work load, blood deficiency, and brain weakness are among a few. Depression, if left untreated can become a permanent condition, interrupting the joys of your life.

Late onset depression is a type of depression that typically occurs in late adulthood, around 65 years of age or older.

And there are studies that claim that growth hormone therapy can help in such cases of depression.

This matter should be looked into with a serious thought, but the tragedy is that only a one third of people facing depression consider having proper treatment to get rid of it. The rest are feared from the social responses they’ll get from friends, coworkers and family.

Among the many symptoms of depression, the gravest one is the thought of attempting suicide by the depressed. Therefore, if you are facing depression yourself, or any of your loved one is going through it, be sure to get it treated on-time! Sadness and despair affects all body parts. The heart, the immune system, the lungs, the digestive system, the sensory organs, and the brain; all are endangered.

The proven and affordable method for curing this disease is through the use of HGH. Human Growth Hormone is the leading hormone controlling and managing the activities of various secondary hormones and metabolism levels in body. Growth hormone is excreted from the pituitary gland placed below the human brain. The excretion heightens during the early morning before waking up. There is an obvious decline in HGH discharge from mid-age onwards. This is also the same age at which biological depression also starts to show in a person.

Abstract:  HGH and Late Onset Depression

Growth hormone is a single-chain, 22,000 molecular weight polypeptide with 191 amino acids produced by the somatotropic cells of the anterior pituitary gland. Growth hormone circulates by binding to a carrier protein. The secretory pattern occurs in several spontaneous bursts that are greatest during nocturnal sleep.1 Growth hormone secretion is age dependent, with high plasma levels found at birth and during the maximal growth period of adolescence. Secretion of growth hormone is modified by external stimuli, endogenous neural rhythms, and the feedback effects of growth hormone itself.2 Synthesis and release of growth hormone are controlled by at least two hypothalamic hormones: growth hormone-releasing hormone, and somatostatin or growth-inhibiting factor.

Both of these hormones are synthesized and released from peptidergic neurons of the hypothalamus and are regulated by a host of central nervous system neurotransmitters and neuropeptides. Once growth hormone-releasing hormone and growth-inhibiting factor are released into the pituitary portal venous system under neuroregulatory control, they exert opposing actions on the synthesis and release of growth hormone.

The anatomic distribution of growth hormone receptors in the central nervous system reveals several regions that contain specific binding sites for this hormone.4 These regions include the choroid plexus, the hippocampus, the hypothalamus, the pituitary gland, the putamen, and the thalamus.

Several studies have shown a decline in growth hormone due to aging. The age-related decrease in the release of growth hormone by the hypothalamus is significant.5 Ho et al.6 found that as aging progresses, there is an associated reduction in the secretion of pituitary growth hormone. Lai et al.7 studied tissue preparations from the choroid plexus, the hippocampus, the hypothalamus, the pituitary gland, the putamen, and the thalamus in a population of men and women who were 39 to 90 years old.

They concluded that after 40 years of age, there is a continuous decrease in growth hormone receptors, with the hypothalamus experiencing the most significant loss. Relevant to our hypothesis, in vivo studies have found that growth hormone binding sites in the hypothalamus may mediate the action of growth hormone on catecholamine turnover.8


Physiological Effects

Growth hormone has anabolic, lipolytic, and antinatriuretic actions. For example, reversal of obesity due to increased adipose tissue is noted with the initiation of growth hormone treatment. Various investigators have also examined hypophysectomy-induced hypertriglyceridemia9,10 and increases in total cholesterol levels.11 Other effects of growth hormone deficiency include a decrease in bone mineral content in adults with childhood-onset deficiency. Growth hormone deficiency in adults has also been associated with adverse changes in body composition and bone mineral density,12 changes in serum lipids, and an increase in other cardiovascular risk factors.13

Shahi et al.14 reported a decrease in cardiac output and oxygen consumption after hypophysectomy. A correlation between ventricular mass and serum insulin-like growth factor-1 (IGF-I) was also significant. Because tests of growth hormone status are tedious and vary in accuracy, alternative measures involving growth hormone-dependent peptides (eg, IGF-I and insulin-like growth factor-binding protein-3 [IGFBP-3]) have been used.15 Further, Salomon et al.u found that adults with growth hormone deficiency had only 70% to 75% of the expected exercise capacity and 90% of the expected maximal heart rate.

Falkheden16 first reported several physiological changes after hypophysectomy. Treatment with thyroxine, corticosteroid, and gonadal steroid replacement therapy did not correct these changes. Basal metabolism, cardiac output, heart rate, stroke volume, glomerular filtration rate, renal plasma blood flow, and blood volume were not altered by the surgery. This study led to an understanding of the role of growth hormone replacement in patients with growth hormone deficiency.

Dr Ronald Klatz explains the role of human growth hormone in depression and stress in his book “Grow Young with GH”:”If HGH has a natural antidepressant effect on the brain, it could be a major reason that we are so optimistic and resilient when we are young. With the decline of GH that comes with age, we not only lose muscle, bone, thymus tissue, body water, and cell division, we lose our joy for life. But with a program of Human Growth Hormone stimulation, we can have it all back again.”

Many other experts and physicians are of the view that HGH effectively reduces stress and improves builds self esteem in a person. The psychological and emotional benefits of treating depression with HGH dose include higher energy and capacity to work, greater emotional control, control of mood swings, and restrain anxiety and depression.

Old age comes more quickly when your hormones level drop down. Once the hormone level is low, your body and mind starts to weaken. This makes you feel grumpy, uptight, and anxious all the time with frequent depression attacks. Thus, replacing and raising your natural hormone (HGH) level is positive measure to control depression.


The Atypical Depression Diagnostic Scale (ADDS)30 categorizes sufferers into among three categories: definite atypical unhappiness (mood reactivity preserved > 50%, 2 positive symptoms hyperphagia, hypersomnia, serious exhaustion, leaden paralysis, rejection sensitivity); probable atypical depression (disposition reactivity preserved > 50%, 1 positive symptom); or simple disposition reactive depression (mood reactivity > 50%, no additional symptoms).

This may be partly because of the increased insight subcortical sufferers have compared to AD patients 100 In first stages there is absolutely no difference in depressive symptomatology between cortical and subcortical dementias. Just a few universal programs designed to avoid the symptoms of depression concentrate on younger children, since the majority are targeted generally at the adolescent inhabitants ( Gillham et al., 1995 ; Barrett and Turner, 2001 ; Farrell and Barrett, 2007 ; Essau et al., 2012 ; Gallegos et al., 2013 ; Rooney et al., 2013 ). Certainly, in today’s review, only four universal kid depression prevention programs were discovered that were targeted at a younger generation (between 8 and 12): the Penn Resiliency Program, Close friends, the Aussie Optimism Plan, and FORTIUS (see Table 5 ).

But if you need to change your daily life for the better, you can improve your disposition, attitude and habits. Most females get the infant blues,” or feel unfortunate or empty, in a few days of having a baby. Extension of ET, for indicator control and disease avoidance, at least until the age group of 60 years, is backed by the results of the WHI E-just trial along with other recent randomized scientific trials. Some types of chemo medications can harm these cells and maintain them from developing and developing just how they should. The decision to use growth hormone ought to be made with your son or daughter’s doctor, and you ought to fully discuss its possible unwanted effects. Clinical Guideline 23. Great ( ?c=91523 ). But, it could hurt the mother and the infant. Moreover, LLD may be regarded as a consequence of accumulating losses across physical, functional, and cultural domains instead of as an actual disorder that should be treated.

Delayed Puberty

Frequently a person will experience a period in their lives if they will have periods of despair. There is some proof that suggests a correlation with hormonal imbalances of cortisol or thyroid hormones. In lots of adults, degrees of cortisol (a tension hormone) are elevated during severe depressive periods and go back to normal when the individual is no more depressed. In kids and adolescents, results have already been quite inconsistent, although there is certainly some proof that hypersecretion of cortisol is certainly associated with more serious depressive symptoms and with an increased odds of recurrence of depression. Too little thyroid hormone mimics depression quite nicely and is routinely examined in sufferers with recent onset depression.

CBT. This therapy helps sufferers reframe situations in even more positive ways. Because sufferers with chronic depression may have entrenched emotions of hopelessness, however, CBT methods may need to become more intensive than normal. One review recommended that therapy happen twice a week instead of once weekly, and that it focus on behaviors or thought procedures most amenable to improve, increasing the opportunity that patients will dsicover progress.

Pavlovic: Hormones influence migraine in females on two different period scales. Migraine is a problem that manifests around menarche and is certainly most common in the 30s and 40s. The regular regularity of migraine will worsen during perimenopausal adjustments; again, it is a period of dramatic hormonal fluctuation. Postmenopausally, migraines generally improve. They are much less frequent and sometimes disappear totally.

HGH and Depression

A significant number of queries regarding the evaluation and treatment of geriatric despair remain unanswered. Because the biochemical substrate of geriatric despair is suggested to vary from that of despair of young adults, antidepressants that combine the favourable side-impact profile with the modification of multiple transmitter systems could confirm valuable. However of also higher importance may be the development of brokers that lack significant drug-to-medication interactions (since most elderly get a number of agents for the treating somatic diseases), have limited undesireable effects and so are neither sedative nor activating. When psychotropic medicines are used, it is crucial to find the agent with a far more favourable side effect profile.

Bad habits that may cause or worsen disposition swings and depression include insufficient exercise, alcohol intake and poor diet. Changes in lifestyle may be all that are essential to alleviate depression, anxiety and various other premenstrual and pre menopause symptoms. Exercise improves disposition. The B vitamins both boost energy so that you feel just like exercising and alleviate nervousness and depression. An excessive amount of sugar, caffeine and processed food items can increase disposition swings and irritability and so are migraine triggers for most women.

Sleep problems are often connected with situations of cultural deprivation, unemployment, or stressful lifestyle events (divorce, bad life behaviors, or poor working circumstances) ( Garbarino et al., 2016 ). In addition, it seems, however, that sleep problems are from the development of depression. This romantic relationship occurs because of how insufficient sleep impacts the hippocampus, heightening neural sensitivity to excitotoxic insult and vulnerability to neurotoxic problems, resulting in a net reduction in gray matter in the hippocampus in the still left orbitofrontal cortex ( Novati et al., 2012 ).

Geriatric experts frequently favor treating insomnia in older people with the hormone melatonin, or a low-dosage formulation of the tricyclic antidepressant doxepin (Silenor). Other possibly sedating antidepressants , such as for example Remeron or trazodone, are also occasionally prescribed for both reasons. The novel sleep help Belsomra also offers demonstrated both efficacy and protection in older adults. If there is no improvement in the rest disorder or melancholy, a psychiatrist or psychopharmacologist may recommend various other medications , psychotherapy , or both.

Nowadays there are medically recognized remedies for both menopause and andropause. The most typical one is hormone replacement unit therapy. There is Testosterone Replacement unit Therapy (TRT) for andropause and Postmenopausal Hormone Therapy (PHT) for menopause, that assist to bring the hormonal amounts back up. However, it is stated that whenever improperly administered, TRT make a difference sperm production and raise the risk of having prostate cancer tumor, stroke and liver toxicity. PHT is certainly likewise reported to be a triggering trigger for stroke among women. Various other symptoms for menopause and andropause are treated for the precise condition experienced. The problem seen here’s that the condition isn’t tackled holistically and there still stay various other symptoms that are untreated.

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