Insulin-like growth factor-1 long arginine 3 (IGF-1 LR3) is a synthetically modified form of insulin-like growth factor-1. It has a much longer half-life than the original form due to its reduced binding to IGF-1 binding proteins.

This prolonged activity can improve cell division and growth, boost fat metabolism, and enable muscle repair and hypertrophy.

Recent studies have also indicated that IGF-1 LR3 can be beneficial in improving lactation in mothers with young children. IGF-1 LR3 has the potential to be an effective tool in the promotion of cell growth and development.

Benefits of IGF-1 LR3

The LR3 variant of Insulin-like Growth Factor 1 has a range of positive effects on the body. It can help to boost protein synthesis, improve metabolism, and increase lean body mass while decreasing fat storage.

Additionally, it can have a regenerative effect on nerve tissues, as well as enhancing antioxidant benefits and ligament strength. It also encourages hyperplasia in muscle cells, which can lead to fuller and more developed muscles. Furthermore, it may even help to improve cognitive functions.

Changes in Weight During IGF-1 Therapy

The use of IGF-1 has been known to lead to a gain in muscle mass, as opposed to water weight, which is often the result of taking steroids. IGF-1 is an effective and safe alternative, as it leads to a more permanent increase in muscle size.

This is due to its ability to cause hyperplasia, which involves the growth and division of new cells in the muscles, as opposed to hypertrophy, which only increases the size of existing cells. This process can lead to a noticeable increase in muscle mass after one or two weeks of taking IGF-1.

Variants of IGF-1: IGF-1 vs IGF-1 LR3 vs DES IGF-1

There are two distinct types of IGF variants: IGF-1 LR3 and DES IGF-1.

IGF-1 has a brief half-life, and so it was modified to create IGF-1 LR3, which has a longer lifespan.

DES IGF-1 is a shortened version of IGF-1 which is up to ten times stronger than the original.

These two variants of IGF-1 are similar, but they have different methods of action, making it possible for them to interact and function in specific, varied ways.


IGF-1 LR3 is a potent variant of IGF-1 with a half-life of 20-30 hours, making it a much more effective form of IGF-1. It binds to cell receptors in muscle cells and promotes muscle growth over a longer period of time. IGF-1 LR3 also helps to reduce glucose intake and encourages the body to burn fat for energy.

Due to its long-lasting effects, it is highly favoured by both patients and physicians, as it eliminates the need for daily injections. IGF-1 LR3 cycles through the body, binding to receptors on muscle cells and providing effects for up to a day, making it a great choice for those looking for a long-term muscle growth solution.


DES IGF-1 is a powerful variant of the regular IGF-1 chain, with a potency that is five times higher than the base IGF-1. It has a much shorter half-life of around 20 to 30 minutes, which makes it a delicate chain that must be used carefully.

Its primary use is in targeted site injections, as it is known to be more effective at stimulating hyperplasia in the muscles than IGF-1 LR3. Furthermore, IGF-1 DES also binds to receptors that have been altered by lactic acid, which is produced in high levels during exercise.

This allows it to attach to mutated receptors, thus promoting tissue growth even during physical activity. As such, DES IGF-1 can be used more frequently and for a longer time than the regular IGF-1 LR3.


The Growth Hormone (GH) is a precursor to IGF-1, but why is IGF-1 preferred over GH?

This is because GH does not directly cause muscle growth, but rather, it signals the body to release IGF-1, which then stimulates muscle growth.

Obtaining GH through a physician is difficult, as one must be diagnosed with Adult Growth Hormone Deficiency Syndrome and fail a GH Stimulation Test in order to get a prescription.

This makes IGF-1 and its variants a more practical and effective solution for some people like athletes, those wanting to lose body fat, or anyone looking to get into shape.

IGF-1 Variant DOSING

IGF-1 should be taken daily, ideally after a workout, for seven days a week. Desensitization is unlikely to occur due to IGF-1’s short half-life. On the other hand, IGF-1 LR3 should be taken daily for seven days a week, but with a maximum protocol of 90 days before taking a break.

During the break, other treatment options can be explored. To get the most out of IGF-1 DES , it should be administered multiple times a day before workout activities, focusing on specific sites and muscles.

To ensure the best results, localized injections should be administered, targeting specific muscle groups, such as the biceps.

Bottomline : Is IGF-1 LR3 better than HGH?

Athletes and bodybuilders often purchase IGF-1 LR3 on the black market, as they believe it will provide them with similar or greater benefits than taking IGF-1 or HGH. However, HGH therapy has been studied much more extensively, and evidence suggests that it is more effective than IGF-1 LR3.

HGH has anabolic effects on muscle tissue, as well as stimulating the breakdown of fat, whereas IGF-1 and its analogs are only capable of mediating the anabolic effects of HGH.

Although HGH therapy can have side effects, these can be avoided by correctly adjusting the dose of the medication. In comparison, IGF-1 LR3 has not been studied in humans, and so there is a risk of unexpected side effects.

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